First, the application of the best hydrophobic agent

    1. Preparation of acid-fast capsules

    Glycerol 22.02kg, distilled water 34.13kg, dimethyl silicone oil 10kg, gelatin 43.85kg, dissolved at 70℃80℃, using conventional methods to prepare capsules.The aldehyde-acetone mixture (1/60) was sprayed onto the capsule. Due to the hydrophobic effect of dimethylsilicone oil, the prepared capsule was not disintegrated in acidic gastric juice for 2 hours, and dissolved in alkaline intestinal solution for 200 ~ 620 seconds, which was stable to enzyme and temperature, and had good mechanical strength.

    2. Lighting of sugarcoated tablets (cage)

    In the polishing operation, the Sichuan wax powder with 2% dimethyl silicone oil will be added to the finished color coat tablets, polishing, sugar coated tablets than without dimethyl silicone oil, bright and beautiful color surface, and moisture-proof effect, to ensure that the sugar coated tablets in the storage period is not bleaching, not mildew.

    3, film coating material

    As a plasticizer of the coating material, the core uses the hydrophobicity and oxidation resistance of dimethyl silicone oil and the outside world, not affected by moisture and oxygen in the air.Function, does not absorb moisture deterioration and the coat layer is firm and smooth.

    Two, the best water-soluble dropping pills coolant.

    Possible behaviors of droplets in condensate include spreading, droplet formation, and mixing.Generally, when a liquid with a lower surface tension is placed in a liquid with a higher surface tension, the surface will spread, and vice versa, it is easy to form droplets.Dimethylsilicone oil is a common water-soluble drop pill coolant with a minimum surface energy (liquid paraffin 0.035N, M, vegetable oil 0.035N, M, dimethylsilicone oil 0.021N/m).

    Three, the only effective antistatic agent in the production of micro powder and pellets

    The pellet or pellet is fluidized in a fluidized bed.Paint mist particles are sprayed onto the surface of the material as it passes through the spray zone, coalescing, spreading, and drying.Attach after, forming a small piece of coat film.After repeated spraying, the film gradually expands, eventually forming a continuous overall coating to achieve the purpose of coating.To ensure safe handling and complete dispersion of the material, an antistatic agent should be added to spray the powder so that the powder does not stick together.

    Dimethylsilicone oil is currently the only pharmaceutical excipient with antistatic effect.The dosage of dimethyl silicone oil as antistatic agent is 0.1% of the weight of powder particles.

    Four, used as a lubricant in solid preparations

    Lubricants are materials added before pressing to give or increase fluidity, resistance to adhesion, and lubricity, thereby facilitating the pressing process.A common name for an accessory.Lubricants can be divided into three categories according to their mechanism of action: Lubricants are auxiliary materials that reduce friction between particles or tablets and the mold.After cleaning the tablet mold, coating with a layer of dimethyl silicone oil can also solve the viscosity and punching problems of some varieties.

    5 Act as a release agent in the production of suppositories and other preparations

    Suppository is a cavity preparation that is dissolved in drugs and substrates and scraped out after being poured into the suppository molding during hot, cold, and molding.

    6. Safe antifoaming agent in reflux extraction and biological fermentation of traditional 



    Chinese medicine

    Chinese medicine extraction and reflux fermentation process will often produce a large number of bubbles and lead to leak or detonation phenomenon such as pot, the common used method is to add a small amount of defoaming agent, defoaming agent surface tension is small, can change the bubble surface tension, the breakdown, can eliminate in the process of Chinese traditional medicine reflux extraction and biological fermentation by gas bubble retention, common defoaming agent are ether, dimethyl silicone oil, or other;Diethyl ether and some components of composite defoaming solution have physiological activities, but their safety has not been recognized.

    Dimethylsilicone oil is the only antifoaming agent approved by the drug supervision department.

    7. Main raw materials of medical antifoaming emulsions

    It can be used for gastroscopic examination of gastrointestinal X-ray defoaming, improve the diagnostic effect, eliminate abdominal distension caused by various reasons.

    Viii. Matrix composition of high-end cream products - dimethyl silicone oil

    As the basis of ointment, it can improve the penetration ability of the drug to the skin, improve the efficacy of the drug, improve the comfort of patients, and improve the dispersion speed of the drug.It is a high-end cream matrix that is delicate, lubricated and pearly shaped with aesthetic sensory intuition and has obvious advantages in the speed of drug release.

    9. Application technology of dimethylsilicone oil in medical devices and pharmaceutical packaging products

    Silicide.Refers to the uniform spraying of dimethyl silicone oil (or thinner) on the surface of the instrument or material, and then drying to coat the surface of the instrument or material.The process of applying a thin layer of dimethyl silicone oil.The degree of silication is generally more suitable for 0.012-0.02mg/c.After silicification treatment, the related properties of the products are obviously improved.